課程資訊
課程名稱
 結構生物學概論
Introduction to Structural Biology 
開課學期
 104-1 
授課對象
 生命科學院  生化科技學系  
授課教師
 楊啟伸 
課號
 BST5008 
課程識別碼
 B22 U0180 
班次
  
學分
 2 
全/半年
 半年 
必/選修
 必修 
上課時間
 星期五3,4(10:20~12:10) 
上課地點
 農化二B10-1 
備註
 系統生物學與生物物理領域課程。先修科目：生物化學或生物化學概論。
總人數上限：80人 
Ceiba 課程網頁
 http://ceiba.ntu.edu.tw/1041BST5008 
課程簡介影片
 
核心能力關聯
 本課程尚未建立核心能力關連
課程大綱
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課程概述

This is a class integrates the concepts of structural biology and bioinformatics. The basic principle of amino acids and structre will be explained first, then the modern methods to resolve atomic resolution of protein structures. The relation of protein structure and function will be emphasized in the third part of this class. Bioinformatic principles, methods and modern developments will be followed. 

課程目標
 1. Understand amino acids and protein structures.
2. Modern approaches to resolve protein structure.
3. Protein structure and function.
4. Software-based analysis of protein sequence.
5. Bioinformatic theories
6. Current developments of bioinformatics methods. 
課程要求
 This class will be taught in English. 
預期每週課後學習時數
  
Office Hours
  
指定閱讀
 待補 
參考書目
 1. David Whitford (2005). Proteins : Structure and Function. John Wiley & Sons, Hoboken, NJ. USA.
2. Gregory A. Petsko and Dagmar Ringe (2003). Protein Structure and Function, 4th ed., New Science Press, Waltham, MA.
3. Materials are updated when new developments occur. 
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 Mid-term 
30% 
  
2. 
 Final exam 
50% 
 Bioinformatic part could composed of presentation, too. 
3. 
 Presentation 
20% 
  
 
課程進度
週次
日期
單元主題
第1週
   1. Concepts of structural biology
2. Software tools for structural biology 
第2週
   Amino acids and structure 
第3週
   Five different basic structural elements: Alpha helix, Beta sheet, Beta turn, Beta bulge and Loop 
第4週
   Happy Birthday, Taiwan! 
第5週
   Five protein structural arrangements. 
第6週
   1. Protein Functional Domain and Classifications.
2. Motif
3. Protein Conformational Changes  
第7週
   Resolving protein structures (1) 
第8週
   Resolving protein structures (2) 
第9週
   Midterm Exam 
第10週
   Pick your group members
1. PDB Files Format
2. Structural Bioinfomatics 
第11週
   BYOC (Bring your own computer) day:
1. Sequence analysis
2. Software usage. 
第12週
   Structural Biology and Biophysics 
第13週
   Structural Biology and Life Science:
1. Cell physiology
 
第14週
   Structural Biology and Life Science:
2. Photoreceptor: protein with chromophore 
第15週
   Structural Biology and Life Science:
3. Membrane proteins: Receptors, Pumps and Channels 
第16週
   Structural Biology and Life Science:
4. Signal transduction through G-proteins 
第17週
   Structural Biology and Life Science:
5. Signal transduction in two-component system